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Abstract

Conventional  gene-based  approaches  ignore  the  modular  nature  of most  human  traits, while pathway enrichment methods produce only illustrative results of limited practical utility. Recently,  new  methods  have  emerged  that  change  the  focus  from  the  whole pathways  to  the  definition  of  elementary circuits  within  them  that have  any  mechanistic  significance.  In  some  cases,  this  invo…</description>
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